Can’t Keep is my favourite of Eddie Vedder’s ukulele songs. It’s quite unusual for a ukulele song and sounds far better and more aggressive than the full band, album version.
For this song he’s at least in tune with himself, if not the rest of the world (perhaps some clever metaphor). But if you want to play along with the video, you’ll have to tune down very slightly.
The riff of the song works very well on the uke. It starts out like this:
And shifts a little for the verse to this:
The strumming for these sections is just up, down (a lot). He switches it up a bit for the ‘I won’t live forever…’ bit. Down, down, up, up, down should get you through that.